Title: PR39, a peptide regulator of angiogenesis
Authors: Li, J ×
Post, M
Volk, R
Gao, Y
Li, M
Metais, C
Sato, K
Tsai, J
Aird, W
Rosenberg, R D
Hampton, T G
Sellke, F
Carmeliet, Peter
Simons, M #
Issue Date: Feb-2000
Series Title: Nature medicine vol:6 issue:1 pages:49-55
Abstract: Although tissue injury and inflammation are considered essential for the induction of angiogenesis, the molecular controls of this cascade are mostly unknown. Here we show that a macrophage-derived peptide, PR39, inhibited the ubiquitin-proteasome-dependent degradation of hypoxia-inducible factor-1alpha protein, resulting in accelerated formation of vascular structures in vitro and increased myocardial vasculature in mice. For the latter, coronary flow studies demonstrated that PR39-induced angiogenesis resulted in the production of functional blood vessels. These findings show that PR39 and related compounds can be used as potent inductors of angiogenesis, and that selective inhibition of hypoxia-inducible factor-1alpha degradation may underlie the mechanism of inflammation-induced angiogenesis.
ISSN: 1078-8956
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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