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Title: Long-term effects of retinal lesions on growth-associated protein 43 (GAP-43) expression in the visual system of adult cats
Authors: Baekelandt, Veerle
Eysel, U T
Orban, Guy ×
Vandesande, Frans #
Issue Date: Apr-1996
Publisher: Elsevier/North-Holland
Series Title: Neuroscience Letters vol:208 issue:2 pages:113-116
Abstract: We have investigated the role of growth-associated protein 43 (GAP-43) in synaptic reorganization in the visual system of adult cats that received binocular central retinal lesions. Different survival times between 3 and 8 months after induction of the lesion were chosen. In the deafferented part of the dorsal lateral geniculate nucleus (dLGN) we found a long-lasting increase in GAP-43 protein, while glial fibrillary acidic protein (GFAP) immunoreactivity, which initially increased due to the degeneration of retinal ganglion cells, slowly subsided over this period. In area 17, the pattern of GAP-43 expression did not provide indications for morphological changes in the cortical architecture following retinal lesions.
URI: 
ISSN: 0304-3940
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Animal Physiology and Neurobiology Section - miscellaneous
Research Group Neurophysiology
Research Group for Neurobiology and Gene Therapy
× corresponding author
# (joint) last author

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