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Title: ADP receptors in platelet activation and aggregation
Authors: Hoylaerts, Marc ×
Oury, C├ęcile
Toth-Zsamboki, E
Vermylen, Jozef #
Issue Date: Sep-2000
Series Title: Platelets vol:11 issue:6 pages:307-309
Abstract: ADP plays a central role in platelet aggregation. Activation of platelets via ADP proceeds via three membrane receptor proteins, two of which are coupled to a G protein and the third one constituting an ion channel mediating rapid Ca2+-influx. Via Ca2+-mobilization, the Gq-coupled P2Y1 receptor acts in concert with the Gi-coupled P2TAC receptor, which functions by lowering intracellular cAMP levels. The importance of Ca2+-influx via the P2X1 ion channel remains to be elucidated.
ISSN: 0953-7104
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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