Title: Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1
Authors: Luttun, Aernout
Tjwa, Marc
Moons, Lieve
Wu, Yan
Angelillo-Scherrer, Anne
Liao, Fang
Nagy, Janice A
Hooper, Andrea
Priller, Josef
De Klerck, Bert
Compernolle, Veerle
Daci, Evis
Bohlen, Peter
Dewerchin, Mieke
Herbert, Jean-Marc
Fava, Roy
Matthys, Patrick
Carmeliet, Geert
Collen, Desire
Dvorak, Harold F
Hicklin, Daniel J
Carmeliet, Peter # ×
Issue Date: Aug-2002
Series Title: Nature medicine vol:8 issue:8 pages:831-40
Abstract: The therapeutic potential of placental growth factor (PlGF) and its receptor Flt1 in angiogenesis is poorly understood. Here, we report that PlGF stimulated angiogenesis and collateral growth in ischemic heart and limb with at least a comparable efficiency to vascular endothelial growth factor (VEGF). An antibody against Flt1 suppressed neovascularization in tumors and ischemic retina, and angiogenesis and inflammatory joint destruction in autoimmune arthritis. Anti-Flt1 also reduced atherosclerotic plaque growth and vulnerability, but the atheroprotective effect was not attributable to reduced plaque neovascularization. Inhibition of VEGF receptor Flk1 did not affect arthritis or atherosclerosis, indicating that inhibition of Flk1-driven angiogenesis alone was not sufficient to halt disease progression. The anti-inflammatory effects of anti-Flt1 were attributable to reduced mobilization of bone marrow-derived myeloid progenitors into the peripheral blood; impaired infiltration of Flt1-expressing leukocytes in inflamed tissues; and defective activation of myeloid cells. Thus, PlGF and Flt1 constitute potential candidates for therapeutic modulation of angiogenesis and inflammation.
ISSN: 1078-8956
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Vesalius Research Centre (-)
Clinical and Experimental Endocrinology
Molecular and Vascular Biology
Laboratory of Immunobiology (Rega Institute)
Animal Physiology and Neurobiology Section - miscellaneous
Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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