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Title: Synthesis of imidazo[1,2-a]pyridines as antiviral agents
Authors: Gueiffier, A ×
Mavel, S
Lhassani, M
Elhakmaoui, A
Snoeck, Robert
Andrei, Graciela
Chavignon, O
Teulade, J C
Witvrouw, Myriam
Balzarini, Jan
De Clercq, Erik
Chapat, J P #
Issue Date: Dec-1998
Series Title: Journal of Medicinal Chemistry vol:41 issue:25 pages:5108-12
Abstract: The synthesis of original imidazo[1,2-a]pyridines bearing a thioether side chain at the 3 position and their antiviral activity are reported. From the synthesized compounds, 4, 15, and 21 were highly active against human cytomegalovirus with a therapeutic index superior to 150. These compounds also showed pronounced activity against varicella-zoster virus. Their structure-activity relationship is discussed.
URI: 
ISSN: 0022-2623
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Molecular Virology and Gene Therapy
× corresponding author
# (joint) last author

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