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Title: HIV-related thrombocytopenia
Authors: Blockmans, Daniel Engelbert ×
Vermylen, Jozef #
Issue Date: Aug-1992
Publisher: Acta clinica belgica
Series Title: Acta Clinica Belgica vol:47 issue:2 pages:117-123
Abstract: HIV-related chronic ITP is caused by an accelerated platelet destruction due to adsorption of circulating immune complexes and to specific anti-platelet antibodies, but perhaps also by a defective thrombopoiesis resulting from invasion of the megakaryocytes by the retrovirus. Treatment is needed when platelet numbers drop beneath 20.10(9)/L or when severe bleeding symptoms occur. Steroids, commercially available immunoglobulins for IV use, AZT and anti-Rh immunoglobulins can be administered, although relapses are frequent after withdrawal of the drugs. Recurrences after splenectomy are far less common, but the progression towards AIDS might be accelerated.
ISSN: 1784-3286
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
Laboratory for Clinical Infectious and Inflammatory Disorders
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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