Title: Evaluation of the anti-HIV activity of statins
Authors: Moncunill, Gemma ×
Negredo, Eugenia
Bosch, Lluís
Vilarrasa, Jaume
Witvrouw, Myriam
Llano, Anuska
Clotet, Bonaventura
Esté, José A #
Issue Date: Oct-2005
Publisher: Gower Academic Journals
Series Title: AIDS vol:19 issue:15 pages:1697-700
Abstract: Recent data suggest that statins block HIV-1 replication, which may have important implications for an alternative treatment for AIDS. We tested different statins in cell culture against HIV and conducted a pilot study in HIV-positive patients receiving simvastatin. No anti-HIV activity was detected at subtoxic concentrations and simvastatin did not induce a significant change in the mean viral load or CD4 cell count in study patients. We caution on the use of statins as antiretroviral agents.
ISSN: 0269-9370
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Virology and Gene Therapy
× corresponding author
# (joint) last author

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