Moncunill, Gemma × Negredo, Eugenia Bosch, Lluís Vilarrasa, Jaume Witvrouw, Myriam Llano, Anuska Clotet, Bonaventura Esté, José A #
Gower Academic Journals
AIDS vol:19 issue:15 pages:1697-700
Recent data suggest that statins block HIV-1 replication, which may have important implications for an alternative treatment for AIDS. We tested different statins in cell culture against HIV and conducted a pilot study in HIV-positive patients receiving simvastatin. No anti-HIV activity was detected at subtoxic concentrations and simvastatin did not induce a significant change in the mean viral load or CD4 cell count in study patients. We caution on the use of statins as antiretroviral agents.