Title: Synthesis and biological activities of (Z) and (E) alpha-ethenyl acyclonucleosides
Authors: Redwane, N ×
Lazrek, H B
Barascut, J L
Imbach, J L
Balzarini, Jan
Witvrouw, Myriam
De Clercq, Erik #
Issue Date: Aug-2001
Publisher: Marcel Dekker
Series Title: Nucleosides, Nucleotides & Nucleic Acids vol:20 issue:8 pages:1439-1447
Abstract: Synthesis of Z and E ethenyl acyclonucleosides (6a-e and 7a-e) via Michael addition of nucleobases with the diethyl acetylenedicarboxylate is described. The structures of compounds have been confirmed by spectral data. New compounds were found to be inactive against DNA and RNA viruses.
ISSN: 1525-7770
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Molecular Virology and Gene Therapy
× corresponding author
# (joint) last author

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