Title: 3-Benzamido, ureido and thioureidoimidazo[1,2-a]pyridine derivatives as potential antiviral agents
Authors: Chaouni-Benabdallah, A ×
Galtier, C
Allouchi, H
Kherbeche, A
Chavignon, O
Teulade, J C
Witvrouw, Myriam
Pannecouque, Christophe
Snoeck, Robert
Andrei, Graciela
Balzarini, Jan
De Clercq, Erik
Fauvelle, F
Enguehard, C
Gueiffier, A #
Issue Date: Dec-2001
Series Title: Chemical & pharmaceutical bulletin vol:49 issue:12 pages:1631-1635
Abstract: This work reports the synthesis and the antiviral activities of 3-benzamido, 3-phenylureido and 3-phenylthioureido derivatives in the imidazo[1,2-a]pyridine series. The structure was proven by NMR spectroscopy. The synthesized compounds were evaluated against a large number of viruses. The 3-phenylthioureido derivative 7 showed moderate activity against human cytomegalovirus (HCMV) in vitro. The crystallographic data for 8 are also reported and explain the absence of activity against human immunodeficiency virus (HIV).
ISSN: 0009-2363
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Molecular Virology and Gene Therapy
× corresponding author
# (joint) last author

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