Title: Are 5'-O-carbamate-2',3'-dideoxythiacytidine new anti-HIV and anti-HBV nucleoside drugs or prodrugs?
Authors: Anastasi, Carole ×
Vlieghe, Patrick
Hantz, Olivier
Schorr, Olivier
Pannecouque, Christophe
Witvrouw, Myriam
De Clercq, Erik
Clayette, Pascal
Dereuddre-Bosquet, Nathalie
Dormont, Dominique
Gondois-Rey, Françoise
Hirsch, Ivan
Kraus, Jean-Louis #
Issue Date: Aug-2003
Series Title: Bioorganic & medicinal chemistry letters vol:13 issue:15 pages:2459-63
Abstract: In contrast to 5'-O-carbonate 3TC derivatives (23, 24), which are clearly 3TC prodrugs, the corresponding 3TC carbamates (15-21 and 25), found to be very stable compounds with respect to enzymatic hydrolysis (cellular lysates and culture cell media) and still active on both HIV-1 and HBV infected cells, may not be 3TC prodrugs. The antiviral properties as well as the mechanism of action of 3TC analogues have been studied and evaluated.
ISSN: 0960-894X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Virology and Chemotherapy (Rega Institute)
Molecular Virology and Gene Therapy
× corresponding author
# (joint) last author

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