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Title: Confirmatory strategy of hepatitis C serology based on two screening assays in a diagnostic setting
Authors: Goubau, Patrick ×
Reynders, M
Beuselinck, K
Nevens, Frederik
Peerlinck, Kathelijne
Desmyter, Jan #
Issue Date: Jun-1997
Publisher: Acta clinica belgica
Series Title: Acta Clinica Belgica vol:52 issue:1 pages:31-35
Abstract: One hundred ninety seven successive sera, positive for anti-hepatitis C virus antibody with a third generation screening enzyme immunoassay (MEIA on IMX, Abbott), were tested with alternative third generation screening assays from two different manufacturers (Sanofi and Ortho), with an immunoblot assay (RIBA 3.0, Chiron), and by reverse transcriptase polymerase chain reaction (RT-PCR). Samples positive by RIBA 3.0 or by RT-PCR were considered as true positives. The positive predictive value of a combination of strong positive results in two screening assays was more than 98%. This combination of results has the same predictive value for detectable viraemia as a positive RIBA 3.0 (86.5%). Using a policy of two successive enzyme immunoassays in this clinical diagnostic setting diminishes the need for supplemental assays by more than 85%.
ISSN: 1784-3286
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Hepatology
Molecular and Vascular Biology
Department of Microbiology & Immunology - miscellaneous
× corresponding author
# (joint) last author

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