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Title: The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system
Authors: Lu, Xiaowei ×
Le Noble, Ferdinand
Yuan, Li
Jiang, Quingjan
De Lafarge, Benjamin
Sugiyama, Daisuke
Bréant, Christiane
Claes, Filip
De Smet, Frederik
Thomas, Jean-Léon
Autiero, Monica
Carmeliet, Peter
Tessier-Lavigne, Marc
Eichmann, Anne #
Issue Date: Nov-2004
Publisher: Nature publishing group
Series Title: Nature vol:432 issue:7014 pages:179-86
Abstract: Blood vessels and nerves are complex, branched structures that share a high degree of anatomical similarity. Guidance of vessels and nerves has to be exquisitely regulated to ensure proper wiring of both systems. Several regulators of axon guidance have been identified and some of these are also expressed in endothelial cells; however, the extent to which their guidance functions are conserved in the vascular system is still incompletely understood. We show here that the repulsive netrin receptor UNC5B is expressed by endothelial tip cells of the vascular system. Disruption of the Unc5b gene in mice, or of Unc5b or netrin-1a in zebrafish, leads to aberrant extension of endothelial tip cell filopodia, excessive vessel branching and abnormal navigation. Netrin-1 causes endothelial filopodial retraction, but only when UNC5B is present. Thus, UNC5B functions as a repulsive netrin receptor in endothelial cells controlling morphogenesis of the vascular system.
URI: 
ISSN: 0028-0836
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Vesalius Research Centre (-)
Molecular and Vascular Biology
Electrical Engineering - miscellaneous
Switch Laboratory
Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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