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Title: Mice lacking factor VII develop normally but suffer fatal perinatal bleeding
Authors: Rosen, E D ×
Chan, J C Y
Idusogie, E
Clotman, F
Vlasuk, G
Luther, T
Jalbert, L R
Albrecht, S
Zhong, L
Lissens, A
Schoonjans, Luc
Moons, Lieve
Collen, Desire
Castellino, F J
Carmeliet, Peter #
Issue Date: Nov-1997
Series Title: Nature vol:390 issue:6657 pages:290-4
Abstract: Blood coagulation in vivo is initiated by factor VII (FVII) binding to its cellular receptor tissue factor (TF). FVII is the only known ligand for TF, so it was expected that FVII-deficient embryos would have a similar phenotype to TF-deficient embryos, which have defective vitello-embryonic circulation and die around 9.5 days of gestation. Surprisingly, we find that FVII-deficient (FVII-/-) embryos developed normally. FVII-/- mice succumbed perinatally because of fatal haemorrhaging from normal blood vessels. At embryonic day 9.5, maternal-fetal transfer of FVII was undetectable and survival of embryos did not depend on TF-FVII-initiated fibrin formation. Thus, the TF-/- embryonic lethal and the FVII-/- survival-phenotypes suggest a role for TF during embryogenesis beyond fibrin formation.
URI: 
ISSN: 0028-0836
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
Animal Physiology and Neurobiology Section - miscellaneous
Laboratory of Angiogenesis and Vascular Metabolism (Vesalius Research Center) (+)
× corresponding author
# (joint) last author

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