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Title: Influence of a vitamin E-deficient diet on prostacyclin production by mesometrial triangles and aortic rings from nondiabetic and diabetic pregnant rats
Authors: Spitz, Bernard ×
Deckmyn, Hans
Van Bree, R
Pijnenborg, Robert
Vermylen, Jozef
Van Assche, Frans Andre #
Issue Date: Feb-1985
Series Title: American Journal of Obstetrics and Gynecology vol:151 issue:1 pages:116-20
Abstract: We investigated the effect of a vitamin E-deficient diet on the synthesis of prostacyclin in nondiabetic and diabetic pregnant rats. In both groups the diet reduced fetal growth and prostacyclin production by mesometrial triangles; it also increased serum lipid peroxides, which are known to inhibit prostacyclin synthesis. Independently of the diet, mesometrial triangles of diabetic rats produced more prostacyclin than those of control rats, whereas an opposite tendency was found in the aortic rings. Our model seems useful for fundamental and pharmacologic studies of the vascular pathology of pregnancy.
ISSN: 0002-9378
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Section Woman - Miscellaneous (-)
Molecular and Vascular Biology
Pathophysiology of Pregnancy Section (-)
Chemistry, Campus Kulak Kortrijk
Interdisciplinary Research Facility Life Sciences, Campus Kulak Kortrijk
Faculty of Medicine - miscellaneous
× corresponding author
# (joint) last author

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