Antiviral activity of Rwandan medicinal plants against human immunodeficiency virus type-1 (HIV-1)
Cos, P × Hermans, N De, Bruyne T Apers, S Sindambiwe, J B Witvrouw, Myriam De, Clercq E Vanden, Berghe D Pieters, L Vlietinck, A J #
Phytomedicine : international journal of phytotherapy and phytopharmacology vol:9 issue:1 pages:62-8
Selected plants used in Rwandan traditional medicine for the treatment of infections and/or rheumatoid diseases were investigated for antiviral activity in vitro against human immunodeficiency virus type-1 (HIV-1). Of the 38 tested 80% ethanolic extracts, belonging to plants of 21 different families only the extracts from the leaves of Aspilia pluriseta (Asteraceae) and Rumex bequaertii (Polygonaceae) had interesting selectivity indices (SI = ratio of the 50% cytotoxic concentration to the 50% effective antiviral concentration) higher than 1. Further fractionation of the initially antivirally inactive ethanolic extract of Tithonia diversifolia, however, led to an aqueous fraction with a high anti-HIV-1 activity (SI > 461), indicating that the cytotoxicity of some plant components may mask the antiviral properties of the active plant substances in total plant extracts.