Title: Antiviral activity of Rwandan medicinal plants against human immunodeficiency virus type-1 (HIV-1)
Authors: Cos, P ×
Hermans, N
De, Bruyne T
Apers, S
Sindambiwe, J B
Witvrouw, Myriam
De, Clercq E
Vanden, Berghe D
Pieters, L
Vlietinck, A J #
Issue Date: Jan-2002
Series Title: Phytomedicine : international journal of phytotherapy and phytopharmacology vol:9 issue:1 pages:62-8
Abstract: Selected plants used in Rwandan traditional medicine for the treatment of infections and/or rheumatoid diseases were investigated for antiviral activity in vitro against human immunodeficiency virus type-1 (HIV-1). Of the 38 tested 80% ethanolic extracts, belonging to plants of 21 different families only the extracts from the leaves of Aspilia pluriseta (Asteraceae) and Rumex bequaertii (Polygonaceae) had interesting selectivity indices (SI = ratio of the 50% cytotoxic concentration to the 50% effective antiviral concentration) higher than 1. Further fractionation of the initially antivirally inactive ethanolic extract of Tithonia diversifolia, however, led to an aqueous fraction with a high anti-HIV-1 activity (SI > 461), indicating that the cytotoxicity of some plant components may mask the antiviral properties of the active plant substances in total plant extracts.
ISSN: 0944-7113
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Virology and Gene Therapy
× corresponding author
# (joint) last author

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