Title: Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis
Authors: Carmeliet, Peter ×
Lampugnani, M G
Moons, Lieve
Breviario, F
Compernolle, Veerle
Bono, F
Balconi, G
Spagnuolo, R
Oostuyse, B
Dewerchin, Mieke
Zanetti, A
Angellilo, A
Mattot, V
Nuyens, Dieter
Lutgens, E
Clotman, F
de Ruiter, M C
Gittenberger-de Groot, A
Poelmann, R
Lupu, F
Herbert, J M
Collen, Desire
Dejana, E #
Issue Date: Jul-1999
Series Title: Cell vol:98 issue:2 pages:147-57
Abstract: Vascular endothelial cadherin, VE-cadherin, mediates adhesion between endothelial cells and may affect vascular morphogenesis via intracellular signaling, but the nature of these signals remains unknown. Here, targeted inactivation (VEC-/-) or truncation of the beta-catenin-binding cytosolic domain (VECdeltaC/deltaC) of the VE-cadherin gene was found not to affect assembly of endothelial cells in vascular plexi, but to impair their subsequent remodeling and maturation, causing lethality at 9.5 days of gestation. Deficiency or truncation of VE-cadherin induced endothelial apoptosis and abolished transmission of the endothelial survival signal by VEGF-A to Akt kinase and Bcl2 via reduced complex formation with VEGF receptor-2, beta-catenin, and phosphoinositide 3 (PI3)-kinase. Thus, VE-cadherin/ beta-catenin signaling controls endothelial survival.
ISSN: 0092-8674
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
Animal Physiology and Neurobiology Section - miscellaneous
Faculty of Medicine - miscellaneous
Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven Centre for Cancer Biology) (+)
× corresponding author
# (joint) last author

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