Title: Vascular progenitors: from biology to treatment
Authors: Luttun, Aernout
Carmeliet, Geert
Carmeliet, Peter # ×
Issue Date: Feb-2002
Publisher: Elsevier science london
Series Title: Trends in cardiovascular medicine vol:12 issue:2 pages:88-96
Abstract: The identification of endothelial progenitor cells (EPCs) in the adult human has forced us to reconsider how new blood vessels grow in physiological and pathological conditions in the adult human. An important question in angiogenesis research is to what extent these progenitors functionally contribute to revascularization of ischemic tissues and and to what extent they can be used for therapeutic angiogenic cell transplantation. Even more challenging is the concept that hematopoietic and other bone-marrow-derived stem cells might be recruited in the context of ischemia to induce neovessel formation. This review discusses some of the recent insights and outstanding questions on EPCs, both from a biological and therapeutic perspective. (Trends Cardiovasc Med 2002; 12:88-96). (C) 2002, Elsevier Science Inc.
ISSN: 1050-1738
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Molecular and Vascular Biology
Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven Centre for Cancer Biology) (+)
× corresponding author
# (joint) last author

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