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Title: Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis
Authors: Angelillo-Scherrer, A
de Frutos, P
Aparicio, C
Melis, Els
Savi, P
Lupu, F
Arnout, Jozef
Dewerchin, Mieke
Hoylaerts, Marc
Herbert, J
Collen, Desire
Dahlbäck, B
Carmeliet, Peter # ×
Issue Date: Feb-2001
Series Title: Nature medicine vol:7 issue:2 pages:215-21
Abstract: The growth arrest-specific gene 6 product (Gas6) is a secreted protein related to the anticoagulant protein S but its role in hemostasis is unknown. Here we show that inactivation of the Gas6 gene prevented venous and arterial thrombosis in mice, and protected against fatal collagen/epinephrine-induced thrombo embolism. Gas6-/- mice did not, however, suffer spontaneous bleeding and had normal bleeding after tail clipping. In addition, we found that Gas6 antibodies inhibited platelet aggregation in vitro and protected mice against fatal thrombo embolism without causing bleeding in vivo. Gas6 amplified platelet aggregation and secretion in response to known agonists. Platelet dysfunction in Gas6-/- mice resembled that of patients with platelet signaling transduction defects. Thus, Gas6 is a platelet-response amplifier that plays a significant role in thrombosis. These findings warrant further evaluation of the possible therapeutic use of Gas6 inhibition for prevention of thrombosis.
ISSN: 1078-8956
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
Biomedical Sciences Group Management - miscellaneous
Biomedical Sciences Teaching Methodology and Practicals
Laboratory of Angiogenesis and Vascular Metabolism (VIB-KU Leuven Centre for Cancer Biology) (+)
× corresponding author
# (joint) last author

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