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Title: Hemophilia factor VIII therapy. B- and T-cell tolerance: from basic concepts to clinical practice
Authors: Saint-Remy, Jean-Marie # ×
Issue Date: Jan-2001
Publisher: Il Pensiero Scientifico
Series Title: Haematologica vol:85 issue:10 Suppl pages:93-6
Abstract: Recent advances in the understanding of the mechanisms by which tolerance develops in both B- and T- cells have led to a re-appraisal of possible methods which could be applicable in clinical settings such as hemophilia patients with inhibitors. Thus, it is now clear that a number of mechanisms operate in such a way as to actively induce anergy of B- or T- cells, or even to specifically delete cells in the periphery. The characteristics inherent to the B- and T- cell repertoires and peripheral pools play a major role in the efficiency and maintenance of tolerance induction. The purpose of this manuscript is to review the mechanisms of tolerance induction briefly so as to provide a framework for the understanding of current and future attempts to achieve Factor VIII unresponsiveness in hemophilia A patients.
URI: 
ISSN: 0390-6078
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular and Vascular Biology
× corresponding author
# (joint) last author

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