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Title: Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development
Authors: Petersen, Helle Heibroch ×
Hilpert, Jan
Jacobsen, Christian
Lauwers, Annick
Roebroek, Anton
Willnow, Thomas E #
Issue Date: May-2004
Series Title: FEBS Letters vol:565 issue:1-3 pages:23-27
Abstract: The intracellular domain (ICD) of the low-density lipoprotein receptor-related protein (LRP) functionally interacts with adaptor proteins both as an integral part of the receptor polypeptide and after proteolytic release. Identification of such adaptors has been difficult because the ICD is self-activating in conventional transcription factor-based yeast two-hybrid screens. We adopted an alternative screen for the ICD that depends on the activation of the Ras-signaling pathway and uncovered the transcription factor MafB as novel ICD interacting protein. MafB is a regulator of hindbrain segmentation and interacts with the ICD through a leucine zipper domain. The ICD co-localizes with MafB to the nucleus and negatively regulates its transcriptional activity, suggesting a possible role for LRP in brain development.
ISSN: 0014-5793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Department of Human Genetics - miscellaneous
Molecular Genetics Section (-)
× corresponding author
# (joint) last author

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