Title: A new member of the proprotein convertase gene family (LPC) is located at a chromosome translocation breakpoint in lymphomas
Authors: Meerabux, J
Yaspo, M L
Roebroek, Anton
Van de Ven, Willem
Lister, T A
Young, B D # ×
Issue Date: Feb-1996
Series Title: Cancer Research vol:56 issue:3 pages:448-451
Abstract: A new member of the proprotein convertase gene family (LPC) has been identified at a chromosome translocation breakpoint occurring in a high grade lymphoma. The translocation t(11;14)(q23;q32) has been molecularly cloned and shown to be the result of a fusion between an intron in the 3' -untranslated region of LPC with a sequence close to the switch region S gamma 4 of the IGH locus. The LPC gene encodes a protein of 785 amino acids with substantial homology to furin and the other members of the proprotein convertase family and represents a novel target for chromosome translocation and subsequent deregulation.
ISSN: 0008-5472
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Molecular Genetics Section (-)
Department of Human Genetics - miscellaneous
× corresponding author
# (joint) last author

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