Title: Functional properties of the epithelial Ca2+ channel, ECaC
Authors: Vennekens, Rudi ×
Droogmans, Guillaume
Nilius, Bernd #
Issue Date: Dec-2001
Series Title: General physiology and biophysics. vol:20 issue:3 pages:239-53
Abstract: ECaC is the first member of a new subfamily of Ca2+ channels embedded in the large TRPC family that includes numerous channel proteins. The channel has been proposed as the main gatekeeper of transcellular Ca2+ transport in kidney and intestine. The functional characterization of this channel is evolving rapidly and may have far reaching consequences for other channels of the TRPC family. The goal of this mini-review is to summarize the major functional and structural characteristics of ECaC, including (i) its proposed functional role, (ii) its channel structure and expression pattern, (iii) its main electrophysiological characteristics and (iv) its regulation.
ISSN: 0231-5882
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Physiology Section (-)
Laboratory of Ion Channel Research
Department of Cellular and Molecular Medicine - miscellaneous
× corresponding author
# (joint) last author

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