Title: In vitro and in vivo evaluation of hypericin for photodynamic therapy of equine sarcoids
Authors: Martens, A ×
de Moor, A
Waelkens, Etienne
Merlevede, Wilfried
de Witte, Peter #
Issue Date: Jan-2000
Publisher: Harcourt
Series Title: The Veterinary Journal vol:159 issue:1 pages:77-84
Abstract: The therapeutic potential of the photodynamic compound, hypericin, in the treatment of equine sarcoids was evaluated. The in vitro cytotoxicity was assessed using three equine cell lines and the observed phototoxic effect was comparable to that on different highly sensitive human cell lines and significantly influenced by the energy density used although independent of the cell type. The in vivo antitumoural action of photodynamic therapy using hypericin was evaluated on three equine sarcoids in a donkey. Four intratumoural injections were given and the tumours were illuminated daily during 25 days. An 81% reduction in tumour volume was obtained at the end of therapy and 2 months later, a 90% reduction was observed. Further experimental work should be performed, but these results suggest that photodynamic therapy using hypericin has a potential for the non-invasive treatment of equine sarcoids.
ISSN: 1090-0233
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biochemistry Section (Medicine) (-)
Laboratory for Pharmaceutical Biology (-)
Laboratory of Protein Phosphorylation and Proteomics
Laboratory of Phosphoproteomics (-)
× corresponding author
# (joint) last author

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