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Title: Ca(2+)-transport ATPases and their regulation in muscle and brain
Authors: Wuytack, Frank ×
Raeymaekers, Luc
De Smedt, Humbert
Eggermont, Jan
Missiaen, Ludwig
Van Den Bosch, Ludo
De Jaegere, S
Verboomen, Hilde
Plessers, L
Casteels, Rik #
Issue Date: Mar-1993
Series Title: Annals of the New York Academy of Sciences. vol:671 pages:82-91
Abstract: Eukaryotic cells express one or more isoforms of a sarco(endo)plasmic reticulum (SERCA) and of a plasma membrane (PMCA) Ca2+ pump. Both the SERCA and PMCA gene transcripts are subject to alternative processing in a differentiation stage-dependent and tissue-dependent manner. The Ca2+ pump isoforms thus generated may present different functional properties. This is exemplified by the SERCA2a and SERCA2b isoforms which differ in their Ca2+ sensitivity. Analysis of the cDNA structures for PMCA1 predicts protein isoforms with variant calmodulin- and phospholipid-binding domains. A comparative study of the tissue-specific mechanisms governing SERCA-PMCA transcript processing and a more detailed study of the functional implication of the PMCA pumps isoform diversity will be challenging subjects for future studies.
ISSN: 0077-8923
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Physiology Section (-)
Research Group Experimental Neurology
Laboratory of Cell Transport (-)
Laboratory of Molecular and Cellular Signaling
Laboratory for Neurobiology (Vesalius Research Center)
Laboratory of Cellular Transport Systems
× corresponding author
# (joint) last author

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