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Title: Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains
Authors: Swinnen, Johan ×
Van Veldhoven, Paul P
Timmermans, Leen
De Schrijver, Ellen
Brusselmans, Koen
Vanderhoydonc, Frank
Van de Sande, Tine
Heemers, Hannelore
Heyns, Walter
Verhoeven, Guido #
Issue Date: Mar-2003
Series Title: Biochemical and Biophysical Research Communications vol:302 issue:4 pages:898-903
Abstract: Fatty acid synthase (FAS) is a key metabolic enzyme catalyzing the synthesis of long-chain saturated fatty acids. It plays a central role in the production of surfactant in fetal lungs, in the supply of fatty components of milk, and in the conversion and storage of energy in liver and adipose tissue. Remarkably high levels of FAS expression are found in the majority of human epithelial cancers. As the role of FAS in cancer cells remains largely unknown, we have initiated studies to assess the fate of newly synthesized lipids in cancer cells and have estimated the contribution of FAS to the synthesis of specific lipid classes by treating the cells with small interfering RNAs targeting FAS. Here, we show that in cancer cells FAS plays a major role in the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains. These are raft-aggregates implicated in key cellular processes including signal transduction, intracellular trafficking, cell polarization, and cell migration. These findings reveal a novel role for FAS, provide important new insights into the otherwise poorly understood mechanisms underlying the control of lipid composition of membrane microdomains, and point to a link between FAS overexpression and dysregulation of membrane composition and functioning in tumor cells.
ISSN: 0006-291X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Pharmacology Section (-)
Laboratory of Lipid Biochemistry and Protein Interactions
Laboratory of Lipid Metabolism and Cancer (+)
× corresponding author
# (joint) last author

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