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Title: The effect of calmodulin on the active calcium-ion transport and (Ca2+ + Mg2+)-dependent ATPase in microsomal fractions of smooth muscle compared with that in erythrocytes and cardiac muscle
Authors: Wuytack, Frank ×
De Schutter, G
Casteels, Rik #
Issue Date: Apr-1981
Series Title: The Biochemical journal. vol:190 issue:3 pages:827-31
Abstract: The Ca2+ uptake and the (Ca2+ + Mg2+)-dependent ATPase of the porcine coronary-artery smooth-muscle microsomal fraction ('microsomes') are only slightly stimulated by calmodulin. The Ca2+ uptake after 2 min in the absence of oxalate, corrected for the ATP-independent binding, increased by a factor of 1.44, whereas the (Ca2+ + Mg2+)-dependent ATPase is stimulated 1.39 times. These findings contrast with the effect observed in human erythrocyte 'inside-out' microsomes. In these vesicles calmodulin increases the Ca2+ uptake after 20 min in an oxalate-free medium and the (Ca2+ + Mg2+)-dependent ATPase respectively by a factor of 3.82 and 6.18. The magnitude of the calmodulin stimulation of the Ca2+ transport in coronary-artery microsomes is similar to that observed in heart microsomes.
ISSN: 0264-6021
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Physiology Section (-)
Laboratory of Cellular Transport Systems
× corresponding author
# (joint) last author

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