Title: The endothelial volume-regulated anion channel, VRAC
Authors: Nilius, Bernd ×
Eggermont, Jan
Droogmans, Guillaume #
Issue Date: 2000
Series Title: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol:10 issue:5-6 pages:313-20
Abstract: We discuss in this short review properties of a volume-regulated anion channel that we have described in vascular endothelial cells. This channel, VRAC (volume-regulated anion channel) is outwardly rectifying with single channel conductances between 10-20pS for inward currents and 40-50pS for outward currents. VRAC is permeable for a wide range of anions, amino acids and organic osmolytes. The estimated pore diameter is approximately 1.1nm. VRAC is gated by a probably complex mechanism in which changes in ionic strength, tyrosine phosphorylation, the cytoskeletal organiser RhoA and possibly caveolin are essentially involved. The molecular candidate for this channel is still elusive. The functional impact of VRAC as a possible mechano-sensor in endothelium and as a regulatory component in the cell cycle, endothelial cell proliferation and possible angiogenesis will be discussed.
ISSN: 1015-8987
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Physiology Section (-)
Laboratory of Ion Channel Research
Department of Cellular and Molecular Medicine - miscellaneous
Laboratory of Cellular Transport Systems
× corresponding author
# (joint) last author

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