Title: (Patho)physiological implications of the novel epithelial Ca2+ channels TRPV5 and TRPV6
Authors: Nijenhuis, Tom ×
Hoenderop, Joost G J
Nilius, Bernd
Bindels, René J M #
Issue Date: Jul-2003
Series Title: Pflügers Archiv : European journal of physiology. vol:446 issue:4 pages:401-9
Abstract: The epithelial Ca(2+) channels TRPV5 and TRPV6 constitute the apical Ca(2+) entry mechanism in active Ca(2+) (re)absorption. These two members of the superfamily of transient receptor potential (TRP) channels were cloned from the vitamin-D-responsive epithelia of kidney and small intestine and subsequently identified in other tissues such as bone, pancreas and prostate. These channels are regulated by vitamin D as exemplified in animal models of vitamin-D-deficiency rickets. In addition, the epithelial Ca(2+) channels might be involved in the multifactorial pathogenesis of disorders ranging from idiopathic hypercalciuria, stone disease and postmenopausal osteoporosis. This review highlights the emerging (patho)physiological implications of these epithelial Ca(2+) channels.
ISSN: 0031-6768
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Ion Channel Research
Department of Cellular and Molecular Medicine - miscellaneous
× corresponding author
# (joint) last author

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