Title: Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences
Authors: Fransen, Marc ×
Wylin, Tine
Brees, Chantal
Mannaerts, Guy
Van Veldhoven, Paul P #
Issue Date: Jun-2001
Series Title: Molecular and cellular biology. vol:21 issue:13 pages:4413-4424
Abstract: The molecular machinery underlying peroxisomal membrane biogenesis is not well understood. The observation that cells deficient in the peroxins Pex3p, Pex16p, and Pex19p lack peroxisomal membrane structures suggests that these molecules are involved in the initial stages of peroxisomal membrane formation. Pex19p, a predominantly cytosolic protein that can be farnesylated, binds multiple peroxisomal integral membrane proteins, and it has been suggested that it functions as a soluble receptor for the targeting of peroxisomal membrane proteins (PMPs) to the peroxisome. An alternative view proposes that Pex19p functions as a chaperone at the peroxisomal membrane. Here, we show that the peroxisomal sorting determinants and the Pex19p-binding domains of a number of PMPs are distinct entities. In addition, we extend the list of peroxins with which human Pex19p interacts to include the PMP Pex16p and show that Pex19p's CaaX prenylation motif is an important determinant in the affinity of Pex19p for Pex10p, Pex11pbeta, Pex12p, and Pex13p.
ISSN: 0270-7306
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmacology Section (-)
Laboratory of Abdominal Transplantation
Laboratory of Lipid Biochemistry and Protein Interactions
× corresponding author
# (joint) last author

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