ITEM METADATA RECORD
Title: Evidence for a trophic action of the glycoprotein hormone alpha-subunit in rat pituitary
Authors: Van Bael, Annemie ×
Denef, Carl #
Issue Date: Nov-1996
Series Title: Journal of neuroendocrinology. vol:8 issue:2 pages:99-102
Abstract: The effect of the alpha-subunit of luteinizing hormone (LH alpha) on lactotroph growth in 14-day-old rat pituitary was studied in vitro using a reaggregate pituitary cell culture system. LH alpha significantly expanded both the total population of cells expressing prolactin mRNA and the number of [3H]thymidine incorporating prolactin mRNA expressing cells. No such effect could be elicited by LH. Both effects were inhibited by simultaneous addition of an anti-LH alpha antiserum but not by normal rabbit serum. Anti-LH alpha antiserum added alone to the cultures caused a small decrease in the number of prolactin mRNA expressing cells and in [3H]thymidine labelling of the latter. It is concluded that LH alpha may be a trophic factor of lactotrophs not only during fetal development, as suggested by others previously, but also during the rapid expansion of this cell type during postnatal life in the rat.
ISSN: 0953-8194
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmacology Section (-)
Physiology Section (-)
× corresponding author
# (joint) last author

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