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Title: A study of the organellar Ca2(+)-transport ATPase isozymes in pig cerebellar Purkinje neurons
Authors: Plessers, L ×
Eggermont, Jan
Wuytack, Frank
Casteels, Rik #
Issue Date: Apr-1991
Publisher: The Society for Neuroscience
Series Title: Journal of Neuroscience vol:11 issue:3 pages:650-6
Abstract: Pig cerebellar Purkinje neurons express a high level of Ca2(+)-transport ATPases in their intracellular Ca2+ stores. This was shown at the mRNA level by Northern blotting and in situ hybridization and at the protein level by Western blotting and immunocytochemistry. The majority of the Ca2(+)-transport ATPases in these neurons belongs to the SERCA2b type (i.e., the Ca2(+)-pump isoform found in most nonmuscle cells). The SERCA2a (cardiac/slow-twitch skeletal/smooth muscle) Ca2(+)-pump isoform is expressed only at very low levels. The main Ca2(+)-pump messenger is 6.0 kilobases long and belongs to a class 4-type processing of SERCA2, which is exclusively confined to the cerebrum and cerebellum. Phospholamban, a regulator of the SERCA2 Ca2(+)-transport ATPase in cardiac/slow-twitch skeletal/smooth muscle, could not be detected in Purkinje neurons.
ISSN: 0270-6474
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Physiology Section (-)
Laboratory of Cellular Transport Systems
× corresponding author
# (joint) last author

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