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Title: Responses of endothelial cells to hypotonic solutions: lack of regulatory volume decrease
Authors: De Smet, Patrick ×
Oike, M
Droogmans, Guillaume
Van Driessche, Willy
Nilius, Bernd #
Issue Date: Nov-1994
Series Title: Pflügers Archiv : European journal of physiology. vol:428 issue:1 pages:94-6
Abstract: Hypotonic stress (HTS) activates a Cl- current and releases intracellular Ca2+ in vascular endothelial cells, but there is no co-activation of K(+)-channels. The concomitant increase in cell volume, as assessed from the changes in endothelial cell thickness, is not followed by a regulatory volume decrease (RVD). This lack compensation of the volume increase may be explained by the absence of a concomitant activation of a K+ outward current, resulting in an insufficient efflux of osmolytes during HTS.
ISSN: 0031-6768
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Physiology Section (-)
Department of Cellular and Molecular Medicine - miscellaneous
Laboratory of Ion Channel Research
× corresponding author
# (joint) last author

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