Title: Do voltage-gated Kv1.1 and inward rectifier Kir2.1 potassium channels form heteromultimers?
Authors: Tytgat, Jan ×
Buyse, Gunnar
Eggermont, Jan
Droogmans, Guillaume
Nilius, Bernd
Daenens, Paul #
Issue Date: Sep-1996
Series Title: FEBS Letters vol:390 issue:3 pages:280-4
Abstract: Possible heteromultimer formation between Kv- and Kir-type K+ channels was investigated, in connection with the known functional diversity of K+ channels in vivo. Voltage-clamp experiments were performed on Xenopus oocytes, either injected with concatenated Kir2.1-Kv1.1 mRNA, or co-injected with Kv1.1 and Kir2.1 mRNA. K+ currents could be approximated by the algebraic sum of the 2 K+ current types alone. The tandem construct did not show functional expression, although it could be detected by Western blotting. We conclude that Kv1.1 and Kir2.1 alpha-subunit proteins fail to assemble and do not contribute functional diversity to K+ channels.
ISSN: 0014-5793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Physiology Section (-)
Toxicology and Pharmacology
Brain & Metabolism Section (-)
Laboratory of Ion Channel Research
Department of Cellular and Molecular Medicine - miscellaneous
Laboratory of Cellular Transport Systems
× corresponding author
# (joint) last author

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