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Title: Presence of small GTP-binding proteins in the peroxisomal membrane
Authors: Verheyden, Kristine
Fransen, Marc
Van Veldhoven, Paul P
Mannaerts, Guy # ×
Issue Date: Sep-1992
Publisher: Elsevier
Series Title: Biochimica et Biophysica Acta. Biomembranes vol:1109 issue:1 pages:48-54
Abstract: Highly purified peroxisomal membranes stripped from their peripheral membrane proteins and only minimally contaminated with other membranes, contained three GTP-binding proteins of 29, 27 and 25 kDa, respectively. Bound radioactive GTP was displaced by unlabelled GTP, GTP analogs and GDP but not by GMP or other nucleotides. GTP binding was markedly decreased by trypsin treatment of intact purified peroxisomes; it increased 2-3-fold after pretreatment of the animals with a peroxisome proliferator. We conclude that the peroxisomal membrane contains small GTP-binding proteins that are exposed to the cytosol and that are firmly anchored in the membrane. We speculate that these proteins are involved in peroxisome multiplication by fission or budding during peroxisome biogenesis and proliferation.
ISSN: 0005-2736
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmacology Section (-)
Laboratory of Lipid Biochemistry and Protein Interactions
× corresponding author
# (joint) last author

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