This item still needs to be validated !
Title: Functional difference between SERCA2a and SERCA2b Ca2+ pumps and their modulation by phospholamban
Authors: Verboomen, Hilde ×
Wuytack, Frank
De Smedt, Humbert
Himpens, Bernard
Casteels, Rik #
Issue Date: Oct-1992
Series Title: The Biochemical journal. vol:286 ( Pt 2) pages:591-5
Abstract: COS 1 cells were transfected with full-length pig stomach sarcoplasmic/endoplasmic reticulum Ca2+ pump (SERCA)2a or SERCA2b cDNA. Ca2+ uptake by microsomes from transfected cells revealed that the Ca2+ affinity of the SERCA2b Ca2+ pump (K0.5 0.17 +/- 0.01 microM) was higher than that of the SERCA2a Ca2+ pump (K0.5 0.31 +/- 0.02 microM). Thapsigargin-sensitivity was found to be identical for the two isoforms. The Ca2+ affinity of both the SERCA2a and SERCA2b Ca2+ pumps was decreased by a factor of two when they were co-expressed with phospholamban.
ISSN: 0264-6021
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Physiology Section (-)
Pharmacology Section (-)
Laboratory of Molecular and Cellular Signaling
Laboratory of Cellular Transport Systems
× corresponding author
# (joint) last author

Files in This Item:

There are no files associated with this item.

Request a copy


All items in Lirias are protected by copyright, with all rights reserved.

© Web of science