Title: A capping domain for LRR protein interaction modules
Authors: Ceulemans, Hugo ×
De Maeyer, Marc
Stalmans, Willy
Bollen, Mathieu #
Issue Date: Sep-1999
Series Title: FEBS Letters vol:456 issue:3 pages:349-51
Abstract: Leucine-rich repeats (LRR) are protein interaction modules which are present in a large number of proteins with diverse functions. We describe here a novel motif (16-19 residues) downstream of the last, incomplete, LRR in a subfamily of LRR proteins. In the U2A' spliceosomal protein, this motif is folded into a cap that shields the hydrophobic core of the LRRs from the solvent. Modelling of the LRR-cap in the imidazoline-1 candidate receptor, using the known structure of U2A' as template, showed a conservation of the basic structural features.
ISSN: 0014-5793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biochemistry Section (Medicine) (-)
Biochemistry, Molecular and Structural Biology Section
Department of Cellular and Molecular Medicine - miscellaneous
Laboratory of Biosignaling & Therapeutics
× corresponding author
# (joint) last author

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