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Title: Dopaminergic stimulation of prolactin release
Authors: Denef, Carl ×
Manet, Danielle
Dewals, R #
Issue Date: Jul-1980
Series Title: Nature vol:285 issue:5762 pages:243-6
Abstract: Prolactin (PRL) secretion from anterior pituitary is believed to be under tonic inhibitory control of dopamine (DA) released from the tubero-infundibular dopaminergic neurones into the hypophysial portal blood. Inhibition of PRL release by DA seems to be mediated by sereospecific DA receptors located in PRL cells. Apomorphine and various ergot alkaloids such as bromocryptine mimic the inhibitory effect of DA both in vivo and in vitro, presumably by a direct agonist action on these 'inhibitory' receptors. We now report that PRL secretion in primary cultures of rat pituitary cells can be stimulated by DA when concentrations a thousand times lower than those required for inhibition are used. Secretion rates above basal release can also be induced by apomorphine and bromocryptine when the 'inhibitory' receptors are blocked with certain DA receptor antagonists.
ISSN: 0028-0836
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmacology Section (-)
× corresponding author
# (joint) last author

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