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Title: Functional characterization of an androgen response element in the first intron of the C3(1) gene of prostatic binding protein
Authors: Claessens, Frank ×
Celis, Linda
Peeters, Benjamin
Heyns, W
Verhoeven, Guido
Rombauts, Wilfried #
Issue Date: Dec-1989
Series Title: Biochemical and Biophysical Research Communications vol:164 issue:2 pages:833-40
Abstract: We demonstrate that the 204 bp intronic gene fragment of C3(1), which has a specific in vitro affinity for the androgen receptor, is able to confer androgen responsiveness to a heterologous promoter. This characteristic is completely destroyed by a single G----T substitution, affecting a 5'-TGTTCT-3' element that closely resembles the consensus sequence of the glucocorticoid and progesterone response elements (GRE/PRE). In fact we could show that this androgen response element (ARE) also acts as a similarly weak GRE or PRE in T-47D cells.
ISSN: 0006-291X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Biochemistry Section (Medicine) (-)
Laboratory of Molecular Endocrinology
× corresponding author
# (joint) last author

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