Title: Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype
Authors: Swinnen, Johan ×
Beckers, Annelies
Brusselmans, Koenraad
Organe, Sophie
Segers, Joanna
Timmermans, Leen
Vanderhoydonc, Frank
Deboel, Lodewijk
Derua, Rita
Waelkens, Etienne
De Schrijver, Ellen
Van de Sande, Tine
Noël, Agnès
Foufelle, Fabienne
Verhoeven, Guido #
Issue Date: Mar-2005
Publisher: Waverly Press
Series Title: Cancer Research vol:65 issue:6 pages:2441-2448
Abstract: Aggressive cancer cells typically show a high rate of energy-consuming anabolic processes driving the synthesis of lipids, proteins, and DNA. Here, we took advantage of the ability of the cell-permeable nucleoside 5-aminoimidazole-4-carboxamide (AICA) riboside to increase the intracellular levels of AICA ribotide, an AMP analogue, mimicking a low energy status of the cell. Treatment of cancer cells with AICA riboside impeded lipogenesis, decreased protein translation, and blocked DNA synthesis. Cells treated with AICA riboside stopped proliferating and lost their invasive properties and their ability to form colonies. When administered in vivo, AICA riboside attenuated the growth of MDA-MB-231 tumors in nude mice. These findings point toward a central tie between energy, anabolism, and cancer and suggest that the cellular energy sensing machinery in cancer cells is an exploitable target for cancer prevention and/or therapy.
ISSN: 0008-5472
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Translational Research in GastroIntestinal Disorders
Laboratory of Protein Phosphorylation and Proteomics
Laboratory of Phosphoproteomics (-)
Laboratory of Lipid Metabolism and Cancer (+)
× corresponding author
# (joint) last author

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