Title: Protein phosphatase 2A on track for nutrient-induced signalling in yeast
Authors: Zabrocki, Piotr
Van Hoof, Christine
Goris, Jozef
Thevelein, Johan
Winderickx, Joris
Wera, Stefaan # ×
Issue Date: Apr-2002
Publisher: Blackwell Science
Series Title: Molecular Microbiology vol:43 issue:4 pages:835-42
Abstract: Early studies identified two bona fide protein phosphatase 2A (PP2A)-encoding genes in Saccharomyces cerevisiae, designated PPH21 and PPH22. In addition, three PP2A-related phosphatases, encoded by PPH3, SIT4 and PPG1, have been identified. All share as much as 86% sequence similarity at the amino acid level. This review will focus primarily on Pph21 and Pph22, but some aspects of Sit4 regulation will also be discussed. Whereas a role for PP2A in yeast morphology and cell cycle has been readily recognized, uncovering its function in yeast signal transduction is a more recent breakthrough. Via their interaction with phosphorylated Tap42, PP2A and Sit4 play a pivotal role in target of rapamycin (TOR) signalling. PPH22 overexpression mimics overactive cAMP-PKA (protein kinase A) signalling and PP2A and Sit4 might represent ceramide signalling targets. The methylation of its catalytic subunit stabilizes the heterotrimeric form of PP2A and might counteract TOR signalling. We will show how these new elements could lead us to understand the role and regulation of PP2A in nutrient-induced signalling in baker's yeast.
ISSN: 0950-382X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Faculty of Medicine - miscellaneous
Molecular Physiology of Plants and Micro-organisms Section - miscellaneous
Laboratory of Protein Phosphorylation and Proteomics
Molecular Microbiology and Biotechnology Section - miscellaneous (-)
Laboratory of Molecular Biology of Leukemia
× corresponding author
# (joint) last author

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