Title: SPCA1 pumps and Hailey-Hailey disease
Authors: Missiaen, Ludwig ×
Raeymaekers, Luc
Dode, Leonard
Vanoevelen, Jo
Van Baelen, Kurt
Parys, Jan
Callewaert, Geert
De Smedt, Humbert
Segaert, Siegfried
Wuytack, Frank #
Issue Date: Aug-2004
Series Title: Biochemical and Biophysical Research Communications vol:322 issue:4 pages:1204-13
Abstract: Both the endoplasmic reticulum and the Golgi apparatus are agonist-sensitive intracellular Ca2+ stores. The Golgi apparatus has Ca2+-release channels and a Ca2+-uptake mechanism consisting of sarco(endo)plasmic-reticulum Ca2+-ATPases (SERCA) and secretory-pathway Ca2+-ATPases (SPCA). SPCA1 has been shown to transport both Ca2+ and Mn2+ in the Golgi lumen and therefore plays an important role in the cytosolic and intra-Golgi Ca2+ and Mn2+ homeostasis. Human genetic studies have provided new information on the physiological role of SPCA1. Loss of one functional copy of the SPCA1 (ATP2C1) gene causes Hailey-Hailey disease, a skin disorder arising in the adult age with recurrent vesicles and erosions in the flexural areas. Here, we review recent experimental evidence showing that the Golgi apparatus plays a much more important role in intracellular ion homeostasis than previously anticipated.
ISSN: 0006-291X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Physiology Section (-)
Laboratory of Dermatology
Laboratory of Cellular Transport Systems
Laboratory of Molecular and Cellular Signaling
Laboratory of Dermatoimmunology (+)
× corresponding author
# (joint) last author

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