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Title: Intronic androgen response elements of prostatic binding protein genes
Authors: Claessens, Frank ×
Celis, Linda
De Vos, P
Peeters, Benjamin
Heyns, Walter
Verhoeven, Guido
Rombauts, Wilfried #
Issue Date: Mar-1993
Series Title: Biochemical and Biophysical Research Communications vol:191 issue:2 pages:688-94
Abstract: Transcription of the genes that code for the different components of Prostatic Binding Protein is dependent on androgens. DNA-cellulose competition assays have demonstrated the presence of regions with affinity for the androgen receptor located immediately upstream and in the first intron of these genes. DNase I footprinting in vitro now reveals the exact binding site of a receptor dimer in the first intron of the C3(1), C3(2) and C1 genes. Gene transfer experiments resulted in the description of functional androgen response elements in the C3 genes. The C1 intronic binding site, however, has a much weaker affinity for the DNA-binding domain of the androgen receptor, a characteristic that might explain its inability to function as an androgen response element in chimeric gene constructs.
ISSN: 0006-291X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Clinical and Experimental Endocrinology
Biochemistry Section (Medicine) (-)
Laboratory of Molecular Endocrinology
× corresponding author
# (joint) last author

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