Title: Quality control of protease inhibitors
Authors: Yekkala, Raja
Adams, Erwin
Van Schepdael, Ann
Hoogmartens, Jos # ×
Issue Date: 8-Sep-2007
Publisher: American Chemical Society and American Pharmaceutical Association
Series Title: Journal of pharmaceutical sciences vol:97 pages:2012-2021
Abstract: Protease inhibitors (PIs) are potent competitive inhibitors of the human immunodeficiency virus (HIV) widely used in the treatment of the acquired immune deficiency syndrome (AIDS) and prescribed in combination with other antiretroviral drugs. So far ten PIs were approved by the United States Food and Drug Administration (FDA) for the treatment of HIV infection. In this mini review, quality control methods of each PI are discussed on the basis of analytical techniques published in the literature. Special attention is given to summarize the LC methods described for the analysis of the selected PIs in both drug substances and products with the available literature till date. (c) 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci.
ISSN: 0022-3549
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Pharmaceutical Analysis
× corresponding author
# (joint) last author

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