Title: Stimulation of Ca-dependent action potentials in mammalian ventricular myocardium by a novel dihydropyridine
Authors: Nilius, Bernd # ×
Issue Date: Jun-1985
Series Title: Biomedica biochimica acta. vol:43 issue:12 pages:1385-97
Abstract: Effects of the novel dihydropyridine compound BAY-K 8644 on Ca-dependent slow action potentials in guinea pig papillary muscles were studied. The maximum upstroke velocity Umax of slow action potentials (sAP) increased in concentrations between 2 X 10(-9) and 2 X 10(-7) mol/1 BAY-K whereas at higher concentrations Umax decreased again. Half maximum effects were obtained at 2.5 X 10(-8) mol/l (20 mol/L K+). The increase in Umax could be antagonized by nifedipine in a similar range of concentrations. The duration of sAP was changed depending on the pacing interval. At short pacing intervals (up to 2 s) sAP were abbreviated by BAY-K. BAY-K also induced a small hyperpolarization in 20 mmol/l K+ and lowered the threshold voltage distinctly. Washing out of BAY-K resulted always in an overshooting lengthening of sAP. BAY-K strongly increased Umax at 40 mmol/l K+. The relationship between Umax and the membrane potential was shifted to increased Umax values. At concentrations higher than 6 X 10(-7) mol/l BAY-K produced oscillatory afterdepolarizations indicating a drug-induced Ca overload. All the experimental findings are consistent with the hypothesis that the novel dihydropyridine compound BAY-K 8644 activates Ca-channels in the mammalian ventricular myocardium.
ISSN: 0232-766X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Ion Channel Research
Department of Cellular and Molecular Medicine - miscellaneous
× corresponding author
# (joint) last author

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