Title: Hypericin as a potential phototherapeutic agent in superficial transitional cell carcinoma of the bladder
Authors: Kamuhabwa, Appolinary
Agostinis, Patrizia
Ahmed, Bisan
Landuyt, Willy
Van Cleynenbreugel, Ben
Van Poppel, Hendrik
de Witte, Peter # ×
Issue Date: Aug-2004
Publisher: Royal Society of Chemistry
Series Title: Photochemical & photobiological sciences vol:3 issue:8 pages:772-80
Abstract: Photodynamic therapy (PDT) involves the local or systemic administration of a photosensitizing drug that, upon light irradiation and presence of oxygen, results in tissue damage such as tumor destruction. Hypericin, a hydroxylated phenanthroperylenequinone, is obtained from Hypericum perforatum plants. Hypericin exhibits a high fluorescence quantum yield, and its presence in the tissue can easily be visualized. Interestingly, when instilled into the human bladders, hypericin selectively accumulates in the bladder carcinoma lesions, with the specificity and sensitivity of detecting CIS reaching up to 98.5 and 93%, respectively. Due to this selective accumulation of hypericin in bladder carcinoma lesions, the compound is now used as a fluorescent diagnostic tool for superficial bladder cancer. However, hypericin is also a photosensitizer with a potent photocytotoxic activity. Taken together, these data indicate that hypericin could be used for whole bladder wall PDT of superficial bladder tumors. This review focuses on the more recent in vitro and in vivo evaluation of hypericin as a photodynamic agent in the treatment of superficial transitional cell carcinoma (TCC) bladder tumors.
ISSN: 1474-905X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory for Pharmaceutical Biology (-)
Biochemistry Section (Medicine) (-)
Urology Section (-)
Laboratory of Experimental Radiotherapy
Laboratory of Cell Death Research & Therapy
× corresponding author
# (joint) last author

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