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Title: [Intracellular calcium-releasing channels as cellular targets for immunophilins: a molecular, functional and structural analysis]
Authors: Bultynck, Geert
Van Acker, K
Missiaen, Ludwig
Callewaert, Geert
Parys, Jan
De Smedt, Humbert #
Issue Date: Nov-2004
Series Title: Verhandelingen - Koninklijke Academie voor Geneeskunde van België. vol:66 issue:4 pages:277-303
Abstract: In this study, the FKBP12-binding properties of IP3Rs and RyRs were compared. Although the primary sequence of IP3Rs en RyRs contained a putative FKBP12-binding site, the functional, molecular and structural properties of these sites appeared to be completely different. For RyRs, FKBPs appear to function as associated proteins that are important for the functional regulation of the channel, thereby stabilizing the RyR complex. For IP3Rs, FKBPs might be involved in the de novo protein synthesis of the IP3Rs and the folding of the peptide chain to a functional IP3R protein, thereby functioning as helper enzymes. Hence, it is very unlikely that they function as associated regulatory proteins of the IP3R. In addition, we provided evidence that FKBP 12 is also an important regulating protein of the Ca(2+)-flux properties of the RyR3. FKBP12 clearly modulated both RyR3-mediated global and local Ca(2+)-responses.
ISSN: 0302-6469
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Physiology Section (-)
Laboratory of Molecular and Cellular Signaling
# (joint) last author

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