Title: On the mechanism of hepatic glycogenolysis induced by anoxia or cyanide
Authors: Bollen, Mathieu ×
De Ruysscher, Dirk
Stalmans, Willy #
Issue Date: Nov-1983
Series Title: Biochemical and Biophysical Research Communications vol:115 issue:3 pages:1033-9
Abstract: Addition of glucagon to isolated hepatocytes increased glycogenolysis and phosphorylase a in a proportional manner. KCN caused slightly more glycogenolysis at considerably lower levels of phosphorylase a; the discrepancy was most pronounced after pretreatment of the hepatocytes with EGTA. When incubated with tagatose, the hepatocytes accumulated tagatose 1-phosphate, a presumed inhibitor of phosphorylase a. In these conditions the glucagon-induced glycogenolysis was blocked, but the glycogen loss caused by KCN or anoxia was not affected. Cyanide and anoxia may allow phosphorylase b and a to become equally active, or they may trigger a non-phosphorolytic glycogenolysis.
ISSN: 0006-291X
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biochemistry Section (Medicine) (-)
Department of Cellular and Molecular Medicine - miscellaneous
Department of Oncology - miscellaneous
Laboratory of Biosignaling & Therapeutics
× corresponding author
# (joint) last author

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