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Title: Bcl-2-dependent modulation of Ca(2+) homeostasis and store-operated channels in prostate cancer cells
Authors: Vanden Abeele, Fabien ×
Skryma, Roman
Shuba, Yaroslav
Van Coppenolle, Fabien
Slomianny, Christian
Roudbaraki, Morad
Mauroy, Brigitte
Wuytack, Frank
Prevarskaya, Natalia #
Issue Date: Jun-2002
Series Title: Cancer cell. vol:1 issue:2 pages:169-79
Abstract: Antiapoptotic oncoprotein Bcl-2 has extramitochondrial actions due to its localization on the endoplasmic reticulum (ER); however, the specific mechanisms of such actions remain unclear. Here we show that Bcl-2 overexpression in LNCaP prostate cancer epithelial cells results in downregulation of store-operated Ca(2+) current by decreasing the number of functional channels and inhibiting ER Ca(2+) uptake through a reduction in the expression of calreticulin and SERCA2b, two key proteins controlling ER Ca(2+) content. Furthermore, we demonstrate that Ca(2+) store depletion by itself is not sufficient to induce apoptosis in Bcl-2 overexpressing cells, and that sustained Ca(2+) entry via activated store-operated channels (SOCs) is required as well. Our data therefore suggest the pivotal role of SOCs in apoptosis and cancer progression.
URI: 
ISSN: 1535-6108
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Physiology Section (-)
Laboratory of Cellular Transport Systems
× corresponding author
# (joint) last author

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