Title: Characterization of the human secretory component gene promoter
Authors: Verrijdt, Guy ×
Swinnen, Johan
Peeters, Benjamin
Verhoeven, Guido
Rombauts, Wilfried
Claessens, Frank #
Issue Date: Feb-1997
Publisher: Elsevier
Series Title: Biochimica et Biophysica Acta. Gene Structure and Expression vol:1350 issue:2 pages:147-154
Abstract: Secretory Component (SC) is a receptor molecule implicated in the transepithelial transport of polymeric immunoglobulins. We have cloned and characterized the first exon, part of the first intron and 3500 bp of the upstream region of the gene and determined the transcription initiation region. A GC rich region immediately upstream of the transcription start region is interrupted by a potential TATA-box (TTTAA) at position -28. Promoter activity was demonstrated in transient transfection experiments in HepG2 and HeLa cells. The smallest fragment still showing transcriptional activity contains 48 bp of SC promoter. A number of putative recognition sites for transcription factors possibly involved in the regulation of SC transcription by steroids, peptide hormones and cytokines were found in the upstream region.
ISSN: 0167-4781
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Biochemistry Section (Medicine) (-)
Research Center of Development Economics, Leuven
Clinical and Experimental Endocrinology
Mechanical Metallurgy Section (-)
Laboratory of Molecular Endocrinology
Laboratory of Lipid Metabolism and Cancer (+)
× corresponding author
# (joint) last author

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