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Title: Dephosphorylation of PKCdelta by protein phosphatase 2Ac and its inhibition by nucleotides
Authors: Srivastava, Jyoti ×
Goris, Jozef
Dilworth, Stephen M
Parker, Peter J #
Issue Date: Apr-2002
Series Title: FEBS Letters vol:516 issue:1-3 pages:265-9
Abstract: The protein phosphatases PP1(c), PP2A(c) and PP2Calpha are shown to dephosphorylate protein kinase Cdelta (PKCdelta) in vitro; of these PP2A(c) displayed the highest specific activity towards PKCdelta. The role of PP2A(c) in the dephosphorylation of PKCdelta in cells was supported by the demonstration that these proteins could be co-immunoprecipitated from NIH3T3 cells. However the observation that binding of Mg-ATP to PKCdelta could protect the enzyme from dephosphorylation by PP2A(c) in vitro indicates that an additional input/factor is required for dephosphorylation in vivo.
URI: 
ISSN: 0014-5793
Publication status: published
KU Leuven publication type: IT
Appears in Collections:Laboratory of Protein Phosphorylation and Proteomics
× corresponding author
# (joint) last author

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